Hello!
In the pinned sections of #Tech_Support of the Duelist Unite discord server it has been noted that this is a bug that is occurring. The solution is to not use windowed mode or run in compatibility mode. The team does not think this is something unique to YGO Omega, as it seems to be a common problem with Unity, the game engine.
This is a link to the post calling out this problem : Discord
And this is the link calling out the solution to the problem: Discord
If you cannot see #Tech_Support, please read the #rules channel first and it will give you access to the rest of the Duelist Unite discord server.
Please mark this as the solution, and the topic will close in the next 24 hours. Thank you!